Multi-scale Framework for Modeling and Control of Fermentation Processes

In this paper, we propose a generalized multi-scale modeling framework for a continuous alcoholic fermentation using Saccharomyces cerevisiae. Based on the developed multi-scale modeling framework, a multi-scale control (MSC) strategy using PID-type controllers is then designed and compared with that of a single-scale control (SCC) strategy. Results indicate that MSC strategy could greatly improve the closed-loop performance. Also, with the right choice of control strategy by embedding micro-scale controller, this study shows that more complex controller algorithms might not be necessary.